Horspath 2nd will open their Cherwell League Division 2 campaign at home to old rivals Tiddington on Saturday, May 10.
The side then travel to Leighton Buzzard Town, who were relegated from Division 1 last season, in week two, before visiting local rivals Oxford 2nd, promoted as Division 3B winners, the following weekend.
Horspath 3rd start their programme with an away game at Dorchester in Division 4B.
Week two sees the side, the only 3rd XI in the division, take on Stonesfield at the Recreation Ground.
The schedule also includes games against Stanton Harcourt, with the away trip on June 7.
Horspath 4th open up with a home game against promoted Stokenchurch 2nd in Division 6C, before visiting Bledlow Ridge 2nd in week two.
A varied fixture list also sees games against Steventon and Harwell International, who were separated by a point at the top of Division 7C last season, Clifton Hampden, East Hanney-based Golden Sparrows and Frieth, newcomers out of the Mid Bucks League, from near Henley-on-Thames.
In the final round of fixtures on Saturday, September 6, the 2nd XI are at home to Westbury, while the 3rd XI entertain Challow & Childrey 2nd and the 4th XI visit Abingdon Vale 2nd.
CHERWELL LEAGUE OPENING DAY FIXTURES
Saturday, May 10
Division 2: Brackley v Witney Swifts, Great & Little Tew v Leighton Buzzard Town, Horspath 2nd v Tiddington, Minster Lovell v Wolverton Town, Oxford 2nd v Westbury.
Division 4B: Dorchester v Horspath 3rd, Kingston Bagpuize v Charlbury, Oxenford 2nd v Cumnor 2nd, Stanton Harcourt v Challow & Childrey 2nd, Stonesfield v Chipping Norton.
Division 6C: Abingdon Vale 2nd v Bledlow Ridge 2nd, Golden Sparrows v Frieth, Harwell International v Didcot 4th, Horspath 4th v Stokenchurch 2nd, Steventon v Clifton Hampden.